"If there's specific resistance to women making movies, I just choose to ignore that as an obstacle for two reasons: I can't change my gender, and I refuse to stop making movies"

This quote implies that Kathryn Bigelow recognizes that there may be biases and obstacles for women in the movie sector, yet she is determined to keep making flicks no matter those difficulties. She is not mosting likely to allow her gender hold her back, as well as will continue to pursue success in spite of any kind of resistance she may encounter.